Primary Anti-D Alloimmunization Induced by "Asian Type" RHD (c.1227G>A) DEL Red Cell Transfusion
نویسندگان
چکیده
Hyung-Seok Yang, M.D., Min Young Lee, M.D., Tae Sung Park, M.D., Sun Young Cho, M.D., Hee Joo Lee, M.D., Gayoung Lim, M.D., Dae Dong Lee, M.D., Seung Hwan Oh, M.D., Duck Cho, M.D., and Kyoung Un Park, M.D. Department of Laboratory Medicine, School of Medicine, Kyung Hee University, Seoul; Blood Laboratory Center, Central, Korean Red Cross, Seoul; Blood Laboratory Center, Nambu, Korean Red Cross, Busan; Department of Laboratory Medicine, Inje University College of Medicine, Busan; Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
منابع مشابه
Application of Multiplex Ligation-Dependent Probe Amplification Assay for Genotyping Major Blood Group Systems Including DEL Variants in the D-Negative Korean Population
BACKGROUND The DEL blood type, a very weak D variant, is a major concern in the field of transfusion medicine because of its potential to cause anti-D alloimmunization. We investigated the molecular basis of serologically D-negative phenotypes, including the DEL type, and the distribution of other blood group systems in the Korean population using the recently developed multiplex ligation-depen...
متن کاملPrimary anti-D immunization by DEL red blood cells.
Extremely weak D variants called DEL are serologically detectable only by adsorption-elution techniques. A nucleotide change of exon 9 in RHD gene, RHD (K409K, 1227G>A) allelic variant is present in almost all the DEL individuals of East Asians. No DEL phenotype has yet been shown to induce a primary alloanti-D immunization in East Asia. A 68-yr-old D-negative Korean man was negative for anti-D...
متن کاملProspective Evaluation of a Transfusion Policy of RhD-Positive Red Blood Cells into DEL Patients in China.
BACKGROUND The D antigen is highly immunogenic, requiring only a small quantity of transfused red blood cells (RBCs) to cause alloimmunization in D- immunocompetent recipients. DEL was reported arousing alloimmunization to true Rh- patients. Molecular studies of the RHD gene have revealed that DEL individuals retain a grossly intact RHD gene or have a portion of RHD in their genomes. Avoiding i...
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Background: Recurrent blood transfusion is a common treatment in patients with thalassemia. The development of antibodies against red blood cell (RBC) antigens complicates RBC cross-matching, enhances the in vivo destruction of transfused cells, accelerates tissue iron overloading, delays the provision of safe transfusion, and reduces health-related quality of life. Materials and Methods: In t...
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The Rhesus (Rh) blood group is the most polymorphic human blood group and it is clinically significant in transfusion medicine. Especially, D antigen is the most important and highly immunogenic antigen. Due to anti-D, it is the cause of the hemolytic disease of the newborn and transfusion reaction. About 0.1%-0.5% of Asian people are RhD-negative, whereas in the Thai population, the RhD-negati...
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عنوان ژورنال:
دوره 35 شماره
صفحات -
تاریخ انتشار 2015